Barry H Smith Selected Research

Sepharose (Agarose)

12/2018	MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells.
2/2018	Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer: Evaluation of a biological-systems approach to cancer therapy (U.S. FDA IND-BB 10091; NCT 02046174, NCT 01053013).
8/2016	Retention of gene expression in porcine islets after agarose encapsulation and long-term culture.
1/2016	First-in-Human Phase 1 Trial of Agarose Beads Containing Murine RENCA Cells in Advanced Solid Tumors.
1/2014	Enhancement of in vitro and in vivo function of agarose-encapsulated porcine islets by changes in the islet microenvironment.
1/2014	No evidence of viral transmission following long-term implantation of agarose encapsulated porcine islets in diabetic dogs.
12/2013	Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4(+) cells with tumor-initiating capability.
7/2011	Streptozotocin is responsible for the induction and progression of renal tumorigenesis in diabetic Wistar-Furth rats treated with insulin or transplanted with agarose encapsulated porcine islets.
2/2011	Three-dimensional culture of mouse renal carcinoma cells in agarose macrobeads selects for a subpopulation of cells with cancer stem cell or cancer progenitor properties.
2/2011	Hydrophilic agarose macrobead cultures select for outgrowth of carcinoma cell populations that can restrict tumor growth.

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Barry H Smith Research Topics

Disease

6	Neoplasms (Cancer) 12/2018 - 02/2011
5	Renal Cell Carcinoma (Grawitz Tumor) 12/2018 - 02/2011
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2018 - 01/2014
3	Diabetes Mellitus 01/2022 - 01/2014
2	Colorectal Neoplasms (Colorectal Cancer) 12/2018 - 02/2018
2	Hyperglycemia 07/2011 - 01/2008
1	Hypoglycemia (Reactive Hypoglycemia) 01/2022
1	Pneumonia (Pneumonitis) 08/2021
1	Inflammation (Inflammations) 02/2018
1	Carcinogenesis 07/2011
1	Carcinoma (Carcinomatosis) 02/2011
1	Body Weight (Weight, Body) 01/2008
1	Weight Gain 01/2007

Drug/Important Bio-Agent (IBA)

10	Sepharose (Agarose)IBA 12/2018 - 02/2011
4	Insulin (Novolin)FDA Link 11/2016 - 01/2007
2	Biological ProductsIBA 12/2018 - 02/2018
2	Blood Glucose (Blood Sugar)IBA 07/2016 - 01/2008
2	Streptozocin (Streptozotocin)FDA Link 01/2014 - 07/2011
1	S-AdenosylhomocysteineIBA 08/2021
1	ErbB Receptors (EGF Receptor)IBA 12/2018
1	Transcription Factors (Transcription Factor)IBA 12/2018
1	Protein Isoforms (Isoforms)IBA 12/2018
1	Tumor Biomarkers (Tumor Markers)IBA 02/2018
1	Lactate Dehydrogenase 5IBA 02/2018
1	AntigensIBA 02/2018
1	Carcinoembryonic AntigenIBA 02/2018
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 02/2018
1	Hypoglycemic Agents (Hypoglycemics)IBA 07/2016
1	Pravastatin (Pravachol)FDA LinkGeneric 01/2014
1	SolutionsIBA 01/2014
1	Docetaxel (Taxotere)FDA Link 12/2013
1	DNA (Deoxyribonucleic Acid)IBA 07/2011
1	Bromodeoxyuridine (BrdU)IBA 02/2011
1	Proteins (Proteins, Gene)FDA Link 02/2011
1	Conditioned Culture MediaIBA 02/2011
1	Caspase 3 (Caspase-3)IBA 02/2011
1	Glucose (Dextrose)FDA LinkGeneric 01/2008

Therapy/Procedure

7	Therapeutics 01/2022 - 01/2007
4	Islets of Langerhans Transplantation 01/2022 - 07/2011
3	Transplantation 01/2014 - 12/2013
1	Precision Medicine 12/2018
1	Heterologous Transplantation (Xenotransplantation) 01/2014
1	Drug Therapy (Chemotherapy) 12/2013